Nummer 4, 2011 - Svenska SjukhusFysikerFörbundet - Studylib

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In the dGEMRIC technique, the negatively charged contrast agent Gd-DTPA 2− (Magnevist, Berlex, NJ) is injected intravenously and diffuses into articular cartilage, with a final concentration inversely proportional to the cartilage GAG concentration 7. The relative GAG concentration is estimated by measuring the T1 values after penetration of The two main 3D techniques that are considered for T1 quantification in dGEMRIC today are 3D-Look-Locker (3D-LL) [ 11, 20] and 3D-variable flip angle (3D-VFA) [ 22, 23 ]. The 3D Look-Locker technique has been validated against the traditional inversion recovery technique. DELAYED GADOLINIUM‐ENHANCED MRI of cartilage (dGEMRIC) is known to be a reliable technique for evaluating the glycosaminoglycan (GAG) concentration of articular cartilage (1, 2). GAGs have side groups that confer a negative charge to the cartilage matrix. Hence, the dGEMRIC technique holds promise for the development of new diagnostic and therapeutic procedures.

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Jun 29, 2011 Therefore, the dGEMRIC technique has a potential to detect early cartilage damage that is obviously critical for decision-making regarding time Delayed gadolinium-enhanced magnetic resonance imaging of cartilage ( dGEMRIC) is sensitive to the glycosaminoglycan content in cartilage that is lost early in What Is the Correlation Among dGEMRIC, T1p, and T2* Quantitative MRI Cartilage Mapping Techniques in Developmental Hip Dysplasia? Melkus, Gerd PhD Herein, we describe the dGEMRIC technique using a new positively charged contrast agent (i.e. dGEMRIC+). Specifically, we report: the synthesis and Methods: dGEMRIC, T2 and native T1 relaxation times of healthy mature human, juvenile porcine technique for reliable assessment of the cartilage PG con-.

Using this technique, the distribution of Gd-(DTPA)2−contrast agent in cartilage after intravenous injection is assessed with quantitative T1 2018-05-16 Current knowledge and importance of dGEMRIC techniques in diagnosis of hip joint diseases Zilkens, Christoph; Tiderius, Carl Johan LU; Krauspe, Ruediger and Bittersohl, Bernd () In Skeletal Radiology 44 (8). p.1073-1083.

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In conclusion, this study demonstrates that the dGEMRIC technique can be used to longitudinally measure changes in T1gd following cartilage repair surgery. SCIENTIFIC ARTICLE Using the dGEMRIC technique to evaluate cartilage health in the presence of surgical hardware at 3T: comparison of inversion recovery and saturation recovery approaches 2012-10-01 · The dGEMRIC technique is based on the electrical polarity of gadolinium [Gd(DPTA) 2− ions] and glycosaminoglycans in the joint.

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The aim of this study was to investigate the potential of combining the benefits of MRA with biochemically sensitive imaging. Therefore, a comparison of ia versus iv contrast agent administration for dGEMRIC in the assessment of hip joint cartilage was performed. Sweden stands up for open access – cancels agreement with Elsevier LUBcat LIBRIS dGEMRIC is a biochemical imaging technique that can assess the charge density of cartilage. Cartilage can respond to increased mechanical loading by increasing charge density. In acetabular dysplasia, there is increased mechanical load due to the shallow acetabulum, which will normalize after pelvic osteotomy. dGEMRIC, or delayed gadolinium-enhanced MRI of cartilage is a technique that can be used quantitatively to assess glycosaminoglycan content of cartilage or qualitatively to asses the overall structures of cartilage.

(dGEMRIC) is a non-invasive imaging method that measures a surrogate for glycosaminoglycan (GAG) concentration in articular cartilage [1]. GAG is a macromolecule whose con- (dGEMRIC) has been shown to be a clinically useful tool for assessing the glycosaminoglycan (GAG) content in cartilage (1–4). Proteoglycans (PGs) are major contrib-utors to the compressive stiffness of cartilage, and are lost in the early stages of osteoarthritis (5). The dGEM-RIC technique measures the T1 relaxation time of car- Since its first description in 20019, the dGEMRIC technique has been used successfully in orthopaedic and rheumatologic research as well as in clinical practice 10, 11, 12. The dGEMRIC technique is based on the electrical polarity of gadolinium [Gd (DPTA)2− ions] and glycosaminoglycans in the joint. Traditionally dGEMRIC has been performed using a two-dimensional T1-weighted inversion recovery (2D-IR) sequence to acquire data for quantitative T1 mapping [ 18, 19 ]. The major advantage of this method is the widespread availability of the sequence and desirable contrast properties (cartilage versus fluid).
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Newer MRI cartilage mapping techniques such as T1 rho (ρ) and T2* have been performed in the The most straightforward application of dGEMRIC or any molecular imaging technique is simply to demonstrate and follow “lesions” in otherwise apparently normal-appearing cartilage. Detection and monitoring of these lesions demonstrate a number of paradigm-changing concepts in the evaluation of cartilage physiology and pathophysiology. Background: Delayed gadolinium enhanced MRI of cartilage (dGEMRIC) is a quantitative method for assessment of glycosaminoglycan content in connective tissues. We hypothesize that the early diagnosis of degenerative changes in the temporomandibular joint could be diagnosed using dGEMRIC technique. Imaging of Cartilage (dGEMRIC) technique is a well-established method for early assessment of cartilage quality in osteoarthritis [1]. Using this technique, the distribution of Gd-(DTPA)2− contrast agent in cartilage after intravenous injection is assessed with quantitative T 1 mapping.

120 p. Research output: Thesis › Doctoral Thesis (compilation) Noninvasive techniques are needed for the assessment of the repair tissue. HYPOTHESIS: Magnetic resonance imaging (MRI) with delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) can give valuable information regarding the quality and quantity of the repaired cartilage lesion. 2021-03-19 · Anterior femoroacetabular impingement (FAI) is associated with labral tears and acetabular cartilage damage in athletic and young patients. Delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) is an imaging method for detecting early damage to cartilage.
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This study evaluates dGEMRIC in patients with preradiographic degenerative cartilage changes. Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) was first described in 1996 as a nondestructive technique for quantitative measurements of glycosaminoglycan (GAG) concentration in articular cartilage samples. (dGEMRIC) is a non-invasive imaging method that measures a surrogate for glycosaminoglycan (GAG) concentration in articular cartilage [1]. GAG is a macromolecule whose con- 2013-07-01 · The non-invasive MR imaging technique called delayed gadolinium enhanced magnetic resonance imaging (MRI) of cartilage (dGEMRIC) can be used to assess the concentration of glycosaminoglycans (GAGs) in the extracellular cartilage matrix 5. 2012-10-01 · Since its first description in 20019, the dGEMRIC technique has been used successfully in orthopaedic and rheumatologic research as well as in clinical practice 10, 11, 12.

2006-11-01 According to the decrease of glycosaminoglycans in cartilage degeneration, more Gd-DTPA2 penetrates into the cartilage, which will cause a reduction of T1 relaxation time that can be measured in milliseconds - "Current knowledge and importance of dGEMRIC techniques in diagnosis of hip joint diseases" The dGEMRIC technique used in this study had already been applied in previous studies [16, 21]. In a study on 30 patients after MACT, with a mean follow-up of 19.61 ± 8.81 months, Trattnig et al. found a mean T1 RT of 427 ± 159 ms and a mean T1 RC of 636 ± 189 ms. Multanen et al The dGEMRIC technique can be easily implemented clinically by using a standard 1.5 or 3.0 T magnet. Although the duration of the total acquisition time (up to 2 hours) diminishes its attractiveness for clinical use, dGEMRIC has potential value in clinical trials, where it has shown the ability to demonstrate changes in morphologically intact cartilage that may be predictive of progression to The dGEMRIC technique has provided valuable results in studies on hip dysplasia , in comparative studies with arthroscopically determined cartilage softening in early osteoarthritis , and demonstrated the positive effects of moderate exercise on GAG content in knee cartilage . Signal polarity restoration in IR sequence for T1-mapping in the DGEMRIC technique. J. Szumowski1, M. Durkan2, K. Heiles3, D. Brown2, E. Schwarz2, and D. Crawford2 1Radiology, Oregon Health & Science University, Portland, OR, United States, 2Oregon Health & Science University, 3Hewlett-Packard Introduction: Loss of glycosaminoglycan (GAG) in cartilage is typically an initiating event in 2020-12-01 The dGEMRIC technique is a potentially useful clinical imaging method that is currently limited by the long imaging time and need for post‐processing.
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PMID: 27568543 [Indexed for MEDLINE] Sammanfattningsvis ter sig dGEMRIC mycket lovande för att öka kunskapen om artrossjukdomens tidiga skeden samt för utvärdering av olika behandlingsfor-mer. Carl Johan Tiderius carl-johan.tiderius@skane.se Avhandling. Carl-Johan Tiderius. Contrast-enhanced MRI of human knee cartilage-clinical applications of the novel dGEMRIC technique to T1 - Current knowledge and importance of dGEMRIC techniques in diagnosis of hip joint diseases.

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Nummer 4, 2011 - Svenska SjukhusFysikerFörbundet

av C Siversson — Verification of the local flip angle correction method for T1 quantification using (dGEMRIC) technique, in which accurate quantification of the T₁ parameter is Noninvasive techniques are needed for the assessment of the repair tissue. the Knee injury and Osteoarthritis Outcome Score and the dGEMRIC technique. Found 5 swedish dissertations containing the words delayed gadolinium-enhanced MRI of cartilage dGEMRIC. 1. Three-dimensional T1 quantification techniques The dGEMRIC MRI requires an injection of a contrast agent, while the T1-rho MRI does not. If the T1-rho is shown to be as useful as the dGEMRIC method it can LIBRIS titelinformation: Contrast-enhanced MRI of human knee cartilage : clinical applications of the novel dGEMRIC technique to study glycosaminoglycan SwePub titelinformation: Contrast-enhanced MRI of human knee cartilage Clinical applications of the novel dGEMRIC technique to study glycosaminoglycan Delayed gadolinium‐enhanced MRI of cartilage (dGEMRIC) in early knee for determination of absorbed dose distributions using MRI technique: basic studies. Delayed gadolinium-enhanced.